Current Issue : July- September Volume : 2012 Issue Number : 3 Articles : 3 Articles
A study was undertaken of the characteristics and Antidiabetic activity of “Melia Azedarach” (Meliaceae) Leaves, native to India, Southern China and Australia; the genus Melia includes four other species, occurring from south East Asia to Northern Australia. Extraction process of Melia Azedarach was carried out by using Ethanol and Limonoids were separated from the ethanolic extract. Furthermore, the phytochemical investigations were performed by using different test and TLC method. An analysis of limonoid was made using column chromatographic, HPLC (High Performance Liquid Chromatography) and FT-IR. Laboratory bioassays were carried out on alloxan induced diabetic rate. Finally, limonoid, flavonoid and sterols containing leaf extracts of M. azedarach were effective in decreasing blood glucose level in alloxan induced diabetic rats....
Eclipta alba (L.) is small branched annual herbaceous plant with a long history of traditional medicines uses in many countries especially in tropical and subtropical regions. The herb has been known for its curative properties and has been utilized as anticancer, analgesic, antibacterial, antihepatotoxic, antihaemorrhagic, antihyperglycemic, antioxidant, immunomodulatory properties and it is considered as a good rejuvenator too. Recent studies showed an antivenom property & corrosion pickling inhibitor action on mild steel in hydrochloric acid. A wide range of chemical compounds including coumestans, alkaloids, thiopenes, flavonoids, polyacetylenes, triterpenes and their glycosides have been isolated from this species. Extracts and metabolites from this plant have been known to possess pharmacological properties. Spreading awareness regarding the multi-facet uses of this novel drug will help to put a step towards disease free life and a healthy approach. This contribution provides a comprehensive review on ethnomedicinal uses, chemical composition, and the pharmacological profile as medicinal plant....
Antioxidants are radical scavengers, which protect the human body against free radicals that may cause pathological conditions such as ischemia, anaemia, asthma, arthritis, inflammation, neuro-degenertion, Parkinson'sdiseases, mongolism, ageing process. Antioxidant compounds in food play an important role as a health protecting factor. A lot of research is being carried out worldwide directed toward finding natural antioxidants of plant origin. Free radicals may be defined as any chemical species that are capable of existing with one or more unpaired outer shell electrons. They are extremely reactive and generally highly unstable. Reactive oxygen species, such as superoxide radical, hydrogen peroxide, hydroxyl radical, and singlet oxygen are of the greatest biological significance. Methanolic extracts of the plant Citrullus fistulosus linn was investigated for its free radical scavenging property by different in-vitro models i.e. 1,1-diphenyl-2 picryl hydrazyl (DPPH), and reducing power. In both the models the metabolic extract of Citrullus fistulosus shown significant antioxidant activity in a dose dependent manner. In reducing power method the EC50 value of standard (Ascorbic acid) was found to be 90µg whereas methanolic extract of Citrullus fistulosus fruit was found to be 145µg. In DPPH Free radical scavenging activity the EC50 value of standard (Ascorbic acid) was found to be 43µg whereas EC50 value for fruit extract was found to be 70µg. It is evident from our study that the methanolic fractions have shown dose dependent increase in free radical scavenging activity....
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